Cytomel is a synthetically form of the natural thyroid hormone 3, 5, 3' triiodothyronine, which has all the pharmacologic activities of the natural substance. Clinically, Cynomel had been often utilized in efforts to have treated Hypothyroidism, which is a thyroid insufficiency, as well as other secondary symptoms such as obesity, metabolic disorders, and fatigue. Thyroid hormones had been characteristically believed to have been able to have exerted most of their actions through the control of protein synthesis. When moderate amounts of Thyroid hormones had been administered, they had been able to have increased the synthesis of RNA and protein, which had often been followed by an increased basal metabolic rate; as well as having stimulated the oxidative enzy;;ne systems. This, in turn, had enhanced the release of free fatty acids from adipose tissue, and had increased the intestinal absorption and peripheral utilization of glucose. When higher concentrations had been apparent, this had generally resulted in the decrease of protein synthesis, and in the increase of the breakdown of glycogen, lipids and protein. The Cynomel compound closely had resembled the natural thyroid hormone, Tricodide-thyronine (L-T3), and under normal circumstances, the thyroid usually had preduced two hormones, L-thyroxine (L-T4) and L4riiodine 4hyronine (L-T3). However, the latter hormone, had been much stronger and more effective of the two, and had been approximately 4 times as potent as L-T4 on a weight basis. When Cynomel had been administered orally, it had been readily available to the body tissue with approximately 95% of the dose being absorbed within 4 hours from the gastrointestinal tract. The biological half-life of Cynomel had been approximately two and a half days, with the maximal pharmacologic response having occurred within 2 or 3 days. This characteristic had also provided for an early clinical response, as the onset of activity had usually ocatired within a few hours. Several seff-amninistering ath€ó€s had generally claimed that the synthetic compound of Cynomel had been able to have produced the same processes in the body, as if the thyroid had been able to have to produced more of the hormone. Consequently, this entity had allowed Cynomel to have been more effective than the compound of Eutirox or Tiroidine,56 which had been other commercially available L-T4 compounds that had been currently available in Mexico. Many athletes had taken advantage of these characteristics which had been able to have stimulated the metabolism, which in turn, had resulted in a faster conversion of the macronutrients of carbohydrates, proteins, and fats. Bodybuilders, had been especially interested in increased fatburning (lipolysis) entities of the compound of Cynomel. Cynomel had been often utilized by competing bodybuilders several weeks prior to competition, as it had aided in having maintained an extremely low fat content, without the extremes of a starvation diet. This distinctive feature also had made it very popular amongst female athletes, due to the fact that women generally had slower metabolisms than men. Administration of Cynomel had allegedly allowed for the ridding of bodyfat, without a drastic caloric restriction. This also had perinined many athletes to have been able to have remained on high calorie diets with the added advantage of having maintained a "ripped" appearance. Athletes who had utilized Cytomel over several weeks, often had experienced a decrease in muscle mass, which had been discovered to have been avoidable or at least delayed, by the simultaneous intake of steroidal compounds anadrol, deca durabolin, dianabol, winstrol, and by the consumption of a protein rich diet. Another advantage which several athletes who had administered low dosages of Cynomel had claimed to have experienced, had been that the simultaneous intake of steroidal compounds had appeared to have become more effective. This possibly may have occurred as a result of the faster conversion of protein. Although some athletes still had utilized the administration of Cynomel, it had not been nearly as popular as it had once appeared to have been. |
